Whole Exome Sequencing analyses the region of the genome that is the exons, which encode for proteins that constitute only 1-2% of total DNA but harbour most causative mutations. It looks for clinically relevant variations at a significantly lower cost than a whole-genome analysis. 

MedGenome provides an advanced Clinical Exome (Ver. 4). This is a focused panel projected to cover ~6,670 of the genes holding most disease-related information, including nuclear and mitochondrial genes. It seeks to block coding, splice, deep intronic variants, and CNVs. Let’s have a look at the Whole Exome Sequencing test cost.

Why Clinical Exome Might Cost Less Than Whole Exome?

The Clinical Exome holds a high value for the diagnosis; however, it has a narrow scope. Compared to the entire Exome, Clinical Exome can be fairly priced as it is focused on a clinically relevant gene set, making it more preferable in genetically heterogeneous or unresolved diagnostic situations.

What Influences the Cost?

The factors of expense include:

• The quality of the test.
• Diverse results in a CAP-accredited laboratory.
• High coverage with ≥99% variant sensitivity.
• Running QC on NA12878 reference samples.
• Test interpretation by clinical molecular geneticists.
• Genetic counselling before and after testing.

These are all critical factors that one can afford, which include all the essentials. Coverage, accuracy, expert interpretation, and counselling highlight the value of testing, making the added cost one that many buyers may find worthwhile.

What You Get for Your Money?

Clinical Exome 4: It is a small panel of selected genes with high results for relevant disease genes, with high sensitivity to the types of variants. 

WES: offers a broader scope than WGS, covering nearly 23,000 genes, intron-exon boundaries, and mitochondrial DNA, though at a uniform depth of >80–100× coverage, it detects SNVs and CNVs, and also provides genetic counselling and an expert review. 

Rapid Exome: It is an accelerated WES, delivering results in about 10 business days for time-sensitive cases (for instance, critically ill newborn babies). 

How Much Does It Cost?

MedGenome’s Clinical Exome (Ver. 4) is positioned as a low-cost alternative to Whole Exome Sequencing (WES), as mentioned on its official page. 

Comparative Clinical Exome tests from other providers in India typically fall within the range of ~₹20,000 to ₹25,000:

• Suburban Diagnostics lists Clinical Exome Sequencing at around ₹23,500
  
• 1mg offers similar tests priced at approximately ₹21,470 (with offers bringing it close to ₹21,500)

These figures provide a reasonable ballpark estimate for how MedGenome’s Clinical Exome (Ver. 4) might be priced—likely lower than standard WES costs but comparable to other clinical-focused panels

Conclusion

If you suspect a genetic disorder and want a complete understanding of one test at an affordable price, then surely Clinical Exome testing is the option for the deepest possible testing at the lowest price. 

For total genetic clarity and massive detection of variants, it is a smart choice; however, the price is considerable. Rapid Exome is for when time is critical; other than that, all opinions for Rapid and Rapid Genomic Exome testing are similar.